The Cerebral Hemodynamic Response to Administration of Hydralazine
نویسندگان
چکیده
منابع مشابه
The cerebral hemodynamic response to administration of hydralazine.
PRECEDING INVESTIGATIONS have shown that administration of hydralazine (1-hydrazinophthalazine) is accompanied by an inerease in cardiac output,1-5 particularly if the decrease in blood pressure subsequent to its administration is not excessive,5 and by increased renal,6 hepatic,4 and coronary7 blood flow. Cerebral blood flow has been reported to be unchanged by hydralazine, even though cerebra...
متن کاملA paradoxical cerebral hemodynamic effect of hydralazine.
Hydralazine is shown to have a very complex cerebral hemodynamic effect. It raises the intracranial pressure which, together with its effect upon systemic blood pressure, reduces the cerebral perfusion pressure. In spite of this and a concomitantly induced hyperventilation by hydralazine, CBF increases with some delay. The conclusion is that hydralazine is a cerebral vasodilator acting immediat...
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The response of the cerebral circulation to exercise has been studied with transcranial Doppler ultrasound (TCD) because this modality provides continuous measurements of blood velocity and is well suited for the exercise environment. The use of TCD as an index of cerebral blood flow, however, requires the assumption that the diameter of the insonated vessel is constant. Here, we examine this a...
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BACKGROUND Organic nitrates such as nitroglycerin and isosorbide dinitrate are useful in the treatment of congestive heart failure (CHF), but tolerance develops rapidly during continuous administration. Because combination therapy of nitrate and hydralazine has been shown to provide both short- and long-term benefit but nitrate alone produces hemodynamic tolerance, we questioned whether hydrala...
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Changes of regional cerebral blood flow from rest to mental activation by a visually presented spatial reasoning test were measured during normo- and hypercapnia in 10 healthy subjects. Hypercapnia, elicited by inhalation of 6% CO2, resulted in similar flow increases in all 32 cortical regions measured. Increases of flow during testing were seen in post-central regions of the brain whether the ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1962
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.25.6.970